Hyperpolarized [1-¹³C]pyruvate magnetic resonance spectroscopic imaging identifies elevated lactate in epileptic tissue.

ABSTRACT: Thirty percent of epilepsy patients have seizures despite best medical therapy. While epilepsy surgery has emerged as a promising treatment option for these patients, surgical outcomes vary considerably between patients and have not significantly improved over the years. These stagnant outcomes can be attributed to poor seizure onset zone and epileptic network localization with currently available tools. Lactate production is a well-known consequence of metabolic reprogramming and biomarker in epilepsy. Detection of lactate elevations using conventional magnetic resonance spectroscopy has been extensively studied as an effective tool to non-invasively detect epileptic brain tissue. However, this method suffers from poor spatial resolution, which limits its clinical utility in presurgical r

SUBMITTER: Jhajharia A 

PROVIDER: S-EPMC12464677 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature