Association between higher serum uric acid levels and cognitive function: a systematic review and meta-analysis.

ABSTRACT:

Background

Serum uric acid (SUA) levels may be associated with cognitive function, but findings have been inconsistent, potentially varying by cognitive domain and sex. We aimed to determine the association of SUA and different domains of cognitive function.

Methods

Five electronic databases were searched to identify relevant peer-reviewed articles. Studies investigating the association between SUA levels and cognitive function were included. Standardized mean difference (SMD) was calculated, and separate meta-analyses were conducted for each of the domains. Risk of bias was assessed using the Newcastle-Ottawa Quality Assessment Scale. Between-study heterogeneity was investigated through subgroup analysis and a meta-regression model using study-level covariates.

Results</

SUBMITTER: Rabbani MG 

PROVIDER: S-EPMC12464678 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature