Comprehensive Pan-Cancer Analysis of TRNT1 as a Potential Biomarker for Breast Cancer.

ABSTRACT: TRNT1, an RNA nucleotide transferase, plays a critical role in cellular processes and may be involved in cancer. However, its role in cancer has not been fully explored. This study aims to explore the potential significance of TRNT1 in cancer, particularly in breast cancer (BC) progression and prognosis. A pan-cancer analysis of TRNT1 was conducted using various online bioinformatics tools, including GEPIA2, cBioPortal, TIMER2, Metascape, and UALCAN, combined with experimental validation. The analysis encompassed gene expression, prognosis, genomic alterations, immune infiltration, and functional enrichment. Additionally, in vitro experiments were performed to further investigate TRNT1's role in BC. TRNT1 is highly expressed in most cancers, with significant correlation to prognosis, espec

SUBMITTER: Li X 

PROVIDER: S-EPMC12464730 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature