Harnessing the copper surface for direct mechanocatalysis: a case study on mechanochemical sulfonylurea synthesis.

ABSTRACT: Direct mechanocatalysis has arisen as a promising tool to achieve synthetic transformations by utilizing reaction vessels and/or media made of a material capable of acting as a source of catalysis. One common metal utilized for this purpose is copper, the surface of which is not a static environment but rather undergoes many transformations (particularly upon exposure to water and oxygen). Here we have utilized in-house developed equipment for work under controlled atmosphere milling, including a composite milling jar design that enables investigating the behaviour of the copper surface in either impact- or shear-dominated milling regimes. We exploit the unique sensitivity to Cu(ii) species of the mechanocatalytic coupling of isocyanate and sulfonamide to form the sulfonylurea diabetic dru

SUBMITTER: Floyd KR 

PROVIDER: S-EPMC12464735 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature