Patient-Reported Importance of Functional Benefit in Geographic Atrophy.

ABSTRACT:

Importance

Intravitreal complement inhibitors injections (IVCIs) slowed progression of geographic atrophy (GA) lesions in several registration phase 3 trials although without benefit for prespecified secondary functional vision outcomes. Patient acceptability of these therapies needs further exploration.

Objective

To quantify the acceptability of IVCI therapy to United Kingdom patients with GA, assuming vision outcome benefits are expected.

Design, setting, and participants

This cross-sectional study took place at 9 geographically dispersed UK National Health Service centers from April 2023 to April 2024 among 153 participants with treatment-naive GA in at least 1 eye.

Exposures

GA in at least 1 eye.

Main outcomes and measures

Main outcomes were (1) acce

SUBMITTER: Dinah C 

PROVIDER: S-EPMC12464851 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature