SOX6 enhances vascular smooth muscle cell phenotypic switching and elevates blood pressure by activating autophagy.

ABSTRACT:

Background

SOX6 has been shown to play a crucial role in the development of the cardiovascular system. However, its potential role in hypertension and vascular function remains unclear.

Methods

In vascular smooth muscle cells (VSMCs), we employed gain- and loss-of-function approaches combined with RNA sequencing, autophagy flux assessment, and phenotype characterization. Additionally, we established a mouse model with Sox6 overexpression via adeno-associated virus 2 (AAV2) to validate the findings in vivo.

Results

We validated the increased expression of SOX6 in hypertension both in vitro and in vivo. Genetic silencing of Sox6 in VSMCs attenuated the phenotypic switching induced by angiotensin II. Conversely, in vivo overexpression of Sox6 led to a significant elevati

SUBMITTER: Ling Q 

PROVIDER: S-EPMC12464868 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature