Euglycemic Diabetic Ketoacidosis and Its Prevention in Elective Surgical Patients Taking Sodium-Glucose Linked Transporter 2 Inhibitors: An International Perspective.

ABSTRACT:

Background

Sodium-glucose linked transporter 2 (SGLT-2) inhibitors are becoming ubiquitous in medical practice. While beneficial in many areas, they have been implicated in a number of cases of euglycemic diabetic ketoacidosis, a serious and potentially fatal complication, in surgical patients. Therefore, it is important for health professionals to have clear guidelines on how to avoid this. The purpose of this study was to collate and evaluate the available guidelines for the perioperative management of patients taking SGLT-2 inhibitors and to outline the pathophysiology of EDKA in surgical patients.

Methods

A review of the available guidelines was performed using databases from 2010 to 2024. Nine guidelines from across the world were identified and reviewed for specific re

SUBMITTER: Selbie JHJ 

PROVIDER: S-EPMC12464960 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature