Catalytic Asymmetric (<i>ene</i>-<i>endo</i>)-Carbonyl-Ene Type Cyclizations.

ABSTRACT: The carbonyl-ene reaction between aldehydes and olefins constitutes a perfectly atom economic approach to homoallylic alcohols with concomitant C-C bond formation. However, the scope of catalytic asymmetric intermolecular versions is currently limited to activated substrates, while of the two intramolecular types only catalytic asymmetric (ene-exo)-carbonyl-ene type cyclizations can be considered mature. The corresponding (ene-endo)-cyclizations would arguably find equal utility in chemical synthesis but remain underdeveloped. Herein, we report an efficient regio- and enantioselective catalytic asymmetric (ene-endo)-carbonyl-ene type cyclization of unbiased alkenyl aldehydes using a strong and confined IDPi Brønsted acid catalyst. High enantioselec

SUBMITTER: Shi L 

PROVIDER: S-EPMC12464972 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature