Macromolecular Diamidobenzimidazole Conjugates Can Activate Stimulator of Interferon Genes.

ABSTRACT: A promising class of stimulator of interferon genes (STING) agonists is the non-nucleotide, small molecule, dimeric amidobenzimidazoles (diABZI), which have recently been incorporated into polymer- and antibody-drug conjugates to improve pharmacokinetics and modulate biodistribution for disease-specific applications. These approaches have leveraged diABZI variants functionalized at the 7-position of the benzimidazole for conjugation and tunable drug release from carriers. However, since this position does not interact with STING and is exposed from the binding pocket when bound in an "open lid" configuration, we sought to evaluate the activity of macromolecular diABZI conjugates that lack stimuli-responsive release and are instead conjugated to polymers via a stable amide linker. By synthe

SUBMITTER: Arora K 

PROVIDER: S-EPMC12464991 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature