Seasonal variation in respiratory syncytial virus-specific IgG concentrations in Northern Plains American Indian children with asthma.

ABSTRACT:

Background

Exposure to respiratory syncytial virus (RSV) during childhood is nearly ubiquitous by age 2 years, and infants who develop severe RSV bronchiolitis are more likely to develop asthma later in life.

Objective

We sought to quantify IgG response to RSV infection in American Indian children with and without asthma and to investigate the environmental, clinical, and genetic factors that associate with varying response.

Methods

We compared immunologic response to previous RSV infection in 319 children with and without asthma from a Northern Plains American Indian community and investigated the role of environmental and genetic factors in levels of RSV-specific IgG.

Results

Overall, we found 73% of children to have high concentrations of RSV-specific IgG (>

SUBMITTER: Erdei E 

PROVIDER: S-EPMC12465034 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature