Intensity of CD23 expression on IgG₁ ⁺ B cells reflects serum IgE level in asthma.

ABSTRACT:

Background

IgE plays a key role in asthma pathogenesis. To produce high-affinity IgE, B cells can undergo IgE class switching through an IgG₁ intermediate stage with repeated antigenic stimulation. Nonetheless, the phenotype of B cells that holds IgE response in asthma patients remains to be fully investigated.

Objectives

We investigated whether IgG₁ ⁺ B cells reflect the magnitude of the IgE response and correlate with asthma phenotype and disease severities in adult asthma patients.

Methods

The frequencies of IgG₁ ⁺, CD23⁺, and CD23⁺IgG₁ ⁺ B cells, along with surface CD23 expression levels in the blood of adult asthma patients (n = 40), were compared with those of nona

SUBMITTER: Baert L 

PROVIDER: S-EPMC12465039 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature