Primary Ewing's sarcoma of the vagina: A rare case report and literature review.

ABSTRACT:

Background

Ewing's sarcoma (ES) is an aggressive malignancy affecting bone and soft tissues, predominantly occurring in the skeletal system. The occurrence of Ewing's sarcoma (ES) or primitive neuroectodermal tumor (PNET) with in the female genital tract is rare. Even rarer is its occurrence in the vagina, with only 22 cases reported to date. Accurate diagnosis necessitates a multifaceted approach that includes morphology, immunohistochemistry, and molecular pathology; the gold standard for diagnosis is next-generation sequencing (NGS), which is characterized by chromosomal translocations resulting in FET-ETS gene fusions.Case description.We present an exceptionally rare case of Ewing's sarcoma in a 35-year-old woman of childbearing age. She exhibited a painless vaginal mass measur

SUBMITTER: Fan D 

PROVIDER: S-EPMC12465042 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature