Metformin interferes with urinary creatinine measurement using enzymatic method.

ABSTRACT: Abnormal reaction curves were observed in urinary creatinine tests in patients with diabetes undergoing metformin therapy. Therefore, we investigated whether metformin interferes with urinary creatinine measurements. First, the reaction curves of urinary creatinine measurements from 328 patients were analyzed, focusing on the maximum reaction speed, final reaction speed, and their ratio. Next, the reaction curves of the creatinine solution with and without metformin were analyzed. To elucidate the mechanism of metformin interference, solutions of creatinine, creatine, sarcosine, and hydrogen peroxide with and without metformin were analyzed using a one-reagent measurement in which reagents 1 and 2 were pre-mixed. As the results, in the 84 patients taking metformin, the maximum reaction spe

SUBMITTER: Yoshimoto A 

PROVIDER: S-EPMC12465047 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature