A quantitative CT perfusion-derived online dynamic nomogram for predicting hemorrhagic transformation after intravenous thrombolysis in acute ischemic stroke.

ABSTRACT:

Purpose

To evaluate the diagnostic value of cerebral perfusion and its predictive ability of hemorrhagic transformation (HT) in acute ischemic stroke (AIS) after intravenous thrombolysis (IVT) using CT perfusion (CTP).

Methods

Retrospective cohort of 55 AIS patients who underwent CTP before IVT was included. Clinical information, such as the National Institutes of Health Stroke Scale (NIHSS) score and history of atrial fibrillation (AF), were collected. CTP parameters, including cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), permeability surface area product (PS), time-to-maximum (Tmax), time to peak (TTP), were measured in pathological hemispheres. Relative values (rCBV, rCBF, rMTT, rPS, rTmax, rTTP) were calculated as pathological-to-asymp

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC12465048 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature