Cost-effectiveness analysis of prostate-specific antigen screening in China: a middle-income population-based microsimulation study.

ABSTRACT:

Background

The significance of prostate-specific antigen (PSA) in reducing the health burden of prostate cancer is widely deliberated. We conducted this study, utilising real-world data, to develop a comprehensive, cost-effectiveness analysis model for PSA screening. By evaluating various screening strategies, we aim to provide policymakers with robust research evidence to inform future PSA screening policies.

Methods

We constructed a microsimulation model to assess 56 conventional population-wide PSA screening strategies based on data from a five-year trial with 104,751 participants, a 20-year multicentre database and parameters collected across China, along with approaches involving genetic risk stratification based on family history, polygenic risk scores, and high-penetr

SUBMITTER: Liu J 

PROVIDER: S-EPMC12465055 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature