Efficacy and safety of colchicine in patients with coronary artery disease: An updated meta-analysis of randomized controlled trials.

ABSTRACT:

Background

Inflammation is associated with an increased risk of adverse cardiovascular events in patients with coronary artery disease (CAD). Colchicine is an anti-inflammatory drug that can be used to improve clinical outcomes in patients with CAD.

Methods

A systematic literature search was conducted across PubMed/MEDLINE, Embase, and Cochrane CENTRAL up to August 2025 to identify randomized controlled trials (RCTs) that reported clinical outcomes with the use of colchicine in CAD. Data for outcomes was extracted and summary estimates were generated using a random effects model.

Results

16 RCTs were included reporting data for 20,601 patients. The pooled analysis demonstrated a non-significant difference between colchicine and control groups for reducing all-cause de

SUBMITTER: Ahmed M 

PROVIDER: S-EPMC12465056 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature