Hesperetin Alleviates Bleomycin-Induced Pulmonary Fibrosis by Modulating Cellular Senescence and Promoting Impaired Autophagy in a CISD2-Dependent Manner.

ABSTRACT: Pulmonary fibrosis is an age-related disease marked by progressive lung function decline and high mortality, with limited treatment options. Hesperetin, a citrus-derived flavonoid with antioxidant and anti-aging properties, has not been thoroughly investigated for its potential in pulmonary fibrosis. This study evaluated the prophylactic potential of hesperetin in pulmonary fibrosis in vivo and in vitro. In vivo experiments demonstrated that hesperetin can significantly reduce cellular senescence in bleomycin-induced pulmonary fibrosis. Activation of Nrf2 signaling was involved in inhibiting cellular senescence and oxidative stress in A549 cells treated with hesperetin. We found that the deficiency of CISD2 contributed to bleomycin-induced pulmonary fibrosis and was associated with the pro

SUBMITTER: Lin Q 

PROVIDER: S-EPMC12465101 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature