Enhanced multienzyme catalytic activity of Mn MOF induced by bioligands for efficient tumor therapy.

ABSTRACT: Nanozymes, as substitutes for natural enzymes, are widely used in various fields, such as cancer treatment. However, most nanozymes have low catalytic activity and selectivity, greatly limiting their clinical applications. Here, we propose a new design concept for nanozymes: modifying nanozymes with suitable multifunctional bioligands. This approach not only endows multiple biological functions but also enhances the multienzyme activity of nanozymes and avoids the effect of surface modification on nanozyme activity. In brief, this paper uses multifunctional bioligands to modify Mn MOF to obtain the nanozyme HPMZIF, which exhibits excellent biocompatibility and tumor-targeting ability. Interestingly, polyethyleneimine (PEI) modification not only effectively enhances the biocompatibility of

SUBMITTER: Ke J 

PROVIDER: S-EPMC12465240 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature