Disseminated Mycobacterium kansasii disease complicating Talaromyces marneffei infection in patient with anti-IFN-γ autoantibodies: a case report.

ABSTRACT:

Background

Patients with immunodeficiency syndromes associated with anti-interferon-gamma (IFN-γ) autoantibodies are prone to a wide range of infections, particularly those caused by intracellular pathogens such as nontuberculous mycobacteria (NTM) or Talaromyces marneffei (T. marneffei). However, disseminated Mycobacterium kansasii (M. kansasii) infection co-occurring with T. marneffei infection is relatively rare. Here, we present a case of disseminated M. kansasii disease complicated by T. marneffei infection in a patient with anti-IFN-γ autoantibodies.

Case presentation

A 52-year-old man presented with a persistent cough, back pain, fever, generalized rash, and multiple enlarged lymph nodes. Chest computed tomography (CT) revealed hilar Masses, and technetium 99m (Tc-99m

SUBMITTER: Wei S 

PROVIDER: S-EPMC12465260 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature