Lipocalin-2 in preoperative cerebrospinal fluid is a biomarker for postoperative delirium after hip fracture surgery in older adults: a prospective cohort study.

ABSTRACT:

Background

Postoperative delirium (POD) is a common central nervous system complication in older adult surgical patients. At present, the mechanism for POD is still unclear. Lipocalin-2 (LCN2) may have an impact on cognitive function, but the relationship between LCN2 and POD has remained unclear. Therefore, we sought to investigate the relationship between the levels of LCN2 in plasma and cerebrospinal fluid (CSF) and the occurrence of POD in older adults undergoing hip fracture surgery.

Methods

We conducted a prospective observational cohort study involving 186 older adults (≥65 years old) who underwent hip fracture surgery under spinal anesthesia. CSF and blood samples were collected. The levels of LCN2, interleukin-6 (IL-6), and interleukin-1 (IL-1) were measured using a

SUBMITTER: Kang N 

PROVIDER: S-EPMC12465281 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature