Personalized transcriptional network analysis links age-related loss of gene coordination to individual biological aging.

ABSTRACT:

Background

Aging is characterized by the decline in biological functions, accompanied by changes in gene-to-gene transcriptional coordination, which can be estimated by expression coordination in gene transcriptional network. Notably, gene networks and coordinated expression relationships (CERs) showed inter-individual variability, while personalized aging-related gene expression coordination dynamics in human cohorts have yet to be investigated.

Methods

In this study, we constructed 15,933 personalized transcriptional networks across 26 tissues from 967 donors aged 20 to 80 years old, using the sample-specific network (SSN) framework based on data from the Gene-Tissue Expression (GTEx) project.

Results

We identified gene-gene CERs and characterized their age-dependen

SUBMITTER: Wang HT 

PROVIDER: S-EPMC12465313 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature