Tracheobronchial infectious diseases in adult-onset immunodeficiency with anti-interferon-gamma autoantibodies.

ABSTRACT:

Background

Anti-interferon (IFN)-γ autoantibodies predispose subjects to infections caused by opportunistic intracellular pathogens and lead to the involvement of multiple well-recognized organs, such as the lungs, skin, and lymph nodes. However, the clinical characteristics of tracheobronchial involvement remain unrecognized.

Methods

A retrospective study was conducted between February 2016 and September 2024, enrolling patients with anti-IFN-γ autoantibodies who had documented evidence of tracheobronchial involvement. The clinical data were analyzed, including demographic information, clinical manifestations, laboratory results, chest computed tomography images, bronchoscopy findings, treatments, and clinical outcomes.

Results

A total of 33 patients were enrolled, w

SUBMITTER: Liang X 

PROVIDER: S-EPMC12465342 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature