Characteristics and prognosis of Her2-negative breast cancer expressing unbalanced hormone receptor.

ABSTRACT: Hormone receptors(HRs), including the Estrogen receptor(ER) and Progesterone receptor(PR), are essential indicators for Breast cancer therapy, while the unbalanced expression effect remains unclear. 106,742 women diagnosed with HER2-negative BC in SEER from 2010 to 2015 were divided into four groups: ER-negative PR-negative (NN), ER-negative PR-positive (NP), ER-positive PR-negative (PN), ER-positive PR-positive (PP). The survival rate of NP was equal to NN (P = 0.65, Hazard Ratio(HR) = 0.960, 95%Confidence Index(CI):0.807-1.144), but worse than PP(P = 0.00017, HR = 0.695, 95%CI:0.575-0.874). The curve of PN was lower than PP(P < 0.0001, HR = 0.753, 95%CI:0.706-0.803), but significantly higher than NN(P < 0.0001, HR = 0.808, 95%CI:0.754-0.866). The effect of PN was worse than that of PP (P

SUBMITTER: Wang T 

PROVIDER: S-EPMC12465370 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature