The association between dyslipidemia and intervertebral disc degeneration: a prospective cohort study based on the UK biobank.

ABSTRACT:

Background

Intervertebral disc degeneration (IDD) is a progressive and debilitating condition associated with aging, inflammation, and metabolic disorders. Although dyslipidemia has been implicated in IDD pathogenesis, large-scale prospective evidence remains limited. This study aimed to investigate the observational association between serum lipid traits and IDD risk using data from the UK Biobank.

Methods

A prospective cohort study was conducted among 298,226 participants (aged 37-73 years; 54.2% female, n = 161,770) without IDD at baseline. Serum lipid levels, including total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), apolipoprotein A (Apo A) and apolipoprotein B (Apo B), were measured a

SUBMITTER: Choi W 

PROVIDER: S-EPMC12465384 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature