Alterations in the plasma concentrations of BDNF, proBDNF, and MMP-9 in patients with schizophrenia.

ABSTRACT: Schizophrenia (SCZ) is a complex psychiatric disorder characterized by altered brain neurotrophic factor signaling. This study aimed to investigate the plasma levels of brain-derived neurotrophic factor (BDNF), its precursor proBDNF, and matrix metalloproteinase-9 (MMP-9) in SCZ patients and their relationships with clinical symptoms and lipid metabolism. Plasma levels of BDNF, proBDNF, and MMP-9 were measured in 105 SCZ patients and 76 healthy controls (HCs), the Chinese version of the Repeatable Battery for the Assessment of Neuropsychological Status (CRDPSS), and the Positive and Negative Syndrome Scale (PANSS). SCZ patients exhibited significantly lower BDNF levels and higher proBDNF and MMP-9 levels compared to HCs. A negative correlation was observed between MMP-9 levels and CRDPSS n

SUBMITTER: Liang Y 

PROVIDER: S-EPMC12465453 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature