Multi-omics analysis reveals disrupted gut microbiota and metabolism in gastric cancer patients with high SIRI.

ABSTRACT:

Background

Inflammation significantly affects the progression of gastric cancer (GC). The Systemic Inflammation Response Index (SIRI) is an emerging prognostic marker for various malignant tumors, including GC. However, the mechanisms by which SIRI influences patient outcomes remain unclear. This study employed a multi-omics approach to analyze GC patients with different SIRI levels, aiming to identify factors underlying differences in prognosis.

Methods

A cohort of 495 GC patients was classified into high SIRI (n = 276) and low SIRI (n = 219) groups using a threshold of 2.6. Kaplan-Meier analysis and Receiver operating characteristic (ROC) curves were used to assess survival outcomes and the predictive accuracy of SIRI compared to other inflammatory markers. Gut microbiota

SUBMITTER: Zou F 

PROVIDER: S-EPMC12465455 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature