Nomogram for predicting tumor-stroma ratio in pancreatic ductal adenocarcinoma using dual-energy computed tomography.

ABSTRACT:

Background

This study aimed to develop and validate a nomogram to predict both the tumor-stroma ratio (TSR) and the overall survival (OS) of patients with pancreatic ductal adenocarcinoma (PDAC) using preoperative dual-energy computed tomography (DECT) parameters.

Methods

153 patients with histopathologically confirmed PDAC who underwent preoperative DECT scans were retrospectively reviewed and divided into high- and low-TSR groups based on histological analyses of surgical specimens. Several DECT parameters of the primary tumor were measured, including the normalized iodine concentration (NIC), effective atomic number, slope of the energy spectrum attenuation curve (K), CT values (40-100 keV), and extracellular volume fraction (ECVf), and analyzed alongside clinical and rad

SUBMITTER: Chen W 

PROVIDER: S-EPMC12465538 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature