Exercise effects on the link between inflammation, metabolic health and hyperuricemia: a prospective cohort study.

ABSTRACT:

Background

Adiposity, insulin resistance, and lipid metabolism abnormalities are established risk factors for hyperuricemia; however, the impact of exercise on these factors remains unclear. Moreover, there is a lack of prospective data regarding the predictive value of these risk factors concerning the timing of hyperuricemia onset.

Methods

From 2017 to 2023, data were prospectively collected from annual health checkups and questionnaires. The primary outcome was the incidence of hyperuricemia, stratified into early-onset (age < 40 years) and late-onset (age > 60). Key predictive indicators included the systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), non-high-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio (N

SUBMITTER: He H 

PROVIDER: S-EPMC12465551 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature