Ligilactobacillus salivarius alleviated intestinal damage induced by Salmonella in mice via regulating microbiota.

ABSTRACT:

Background

Salmonella is a major foodborne etiological agent with serious drug resistance, and the pursuit of novel therapeutic agents for the prevention and control of Salmonella infections is of paramount significance.

Purpose

This study aimed to investigate the regulatory effects of Ligilactobacillus salivarius (L. salivarius) on intestinal damage in mice infected with Salmonella.

Methods

Thirty healthy, four-week-old ICR mice were divided into three groups: a control group, an infection model group, and a L. salivarius treatment group. Specifically, mice in the treatment group were orally administered L. salivarius for 15 days before being infected with Salmonella. Following a 24-hour post-infection period, samples were collected from the duodenum, jejunum, ileum,

SUBMITTER: Liang X 

PROVIDER: S-EPMC12465566 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature