Shared and distinct molecular pathways in eutopic endometrium of endometriosis and adenomyosis patients: a transcriptomic study in Chinese women.

ABSTRACT:

Background

Endometriosis (EMs) and adenomyosis (AD) are prevalent gynecological disorders with overlapping symptoms but potentially distinct pathophysiology. This study was to understand different gene expression patterns of eutopic endometrium between EMs and AD in Chinese populations.

Methods

This study investigated transcriptomic profiles of eutopic endometrium in Chinese women with EMs (n = 25), AD (n = 22), and controls (n = 18) to identify shared and disease-specific gene expression patterns.

Results

RNA sequencing and bioinformatic analyses revealed 370 differentially expressed genes (DEGs) between EMs and controls, as well as 309 DEGs between AD and controls. Both conditions showed significant downregulation of immune-related pathways compared to controls, tho

SUBMITTER: Bao J 

PROVIDER: S-EPMC12465589 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature