Nonlinear dose-response relationship between dietary inflammatory index and risk of depression: a systematic review and meta-analysis.

ABSTRACT:

Background

Depression is a prevalent mental health disorders that impose a significant global health burden. Emerging evidence suggests that diet plays a critical role in mental health, primarily through its impact on inflammation. The Dietary Inflammatory Index (DII) is a validated tool designed to assess the inflammatory potential of an individual's diet.

Objective

To systematically evaluate the association between DII and the risk of depression.

Methods

A comprehensive search was conducted in PubMed, Cochrane Library, Embase, and Web of Science from inception to August 9, 2025. Two independent reviewers screened the studies, extracted data, and assessed methodological quality. A meta-analysis was performed to evaluate the association between DII and depression (the

SUBMITTER: Yu L 

PROVIDER: S-EPMC12465630 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature