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Soluble urokinase plasminogen activator receptor promotes endoplasmic reticulum stress and apoptosis susceptibility through RAGE in sepsis acute kidney injury.
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ABSTRACT:
SUBMITTER: Wang B
PROVIDER: S-EPMC12465643 | biostudies-literature | 2025 Sep
REPOSITORIES: biostudies-literature
Publications
Soluble urokinase plasminogen activator receptor promotes endoplasmic reticulum stress and apoptosis susceptibility through RAGE in sepsis acute kidney injury.
Molecular medicine (Cambridge, Mass.) 20250926 1
BACKGROUND: Acute kidney injury (AKI) is a common complication among critically ill patients, associated with an increased risk of adverse outcomes. There is an urgent need for novel biomarkers to assist in the early detection and management of AKI. Soluble urokinase plasminogen activator receptor (suPAR) is an inflammation-related, immune-derived molecule implicated in the pathogenesis of several diseases, including kidney diseases. METHODS: We characterized the ability of serum suPAR levels to ...[more]