Rapid in situ microwave-assisted fabrication of ultrabright near-infrared probe for low-dose in vivo inflammatory imaging.

ABSTRACT: Fluorescent probes operating within the near-infrared second window (NIR-II, 1000-1700 nm), characterized by high tissue transparency and minimal tissue-induced photon scattering/absorption, have been widely applied for early-stage disease diagnosis. However, the capability of NIR-II emitters for deep-tissue imaging is limited by relatively low brightness, which hinders the acquisition of images at low excitation intensity and administration dose. Herein, we introduce a novel in situ strategy to fabricate ultrabright Ag₂S nanoparticles (Ag₂S super NPs) via aftertreatment of chemically synthesized Ag₂S NPs, where a protective shell grown by a 2-minutes rapid microwave irradiation. This shell effectively reduces the surface and structural defects, resulting i

SUBMITTER: Ruan D 

PROVIDER: S-EPMC12465668 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature