Molecular epidemiology and increasing macrolide resistance of Bordetella pertussis isolates in Guangzhou, China.

ABSTRACT:

Background

Pertussis (whooping cough), a highly contagious respiratory disease caused by Bordetella pertussis, has resurged worldwide and requires increased attention. This study aimed to characterize the molecular epidemiology and antimicrobial susceptibility profiles of B. pertussis isolates circulating in Guangzhou, China.

Methods

A total of 91 culture-confirmed pertussis cases in Guangzhou between January 2020 and August 2024 were enrolled and studied. B. pertussis isolates (from January 2020 to May 2024) were recovered from 62 cases. All isolates underwent antigenic genotyping and phylogenetic analysis based on whole-genome sequencing. Antimicrobial susceptibility testing using E-test was performed on 12 representative isolates.

Results

The majority of culture-co

SUBMITTER: Mai Q 

PROVIDER: S-EPMC12465671 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature