Wound healing effects of exosomes from hypoxia- and normoxia-expanded adipose-derived stem cells of infant and adult origin.

ABSTRACT:

Background

Exosomes derived from adipose-derived stem cells (ADSC-Exos) have emerged as promising therapeutic agents for promoting wound healing through paracrine mechanisms. While adult ADSC-Exos have been extensively studied, those derived from infant ADSCs have received limited attention, despite their potentially superior regenerative capacity. In addition, hypoxia preconditioning has been shown to enhance the therapeutic efficacy of stem cells and their secretome; however, its influence on exosome function across different donor ages remains unclear. This study aimed to evaluate and compare the wound healing effects of ADSC-Exos from adult and infant sources expanded under hypoxic and normoxic conditions in a diabetic mouse model.

Methods

ADSC-Exos were isolated from ad

SUBMITTER: Wu SH 

PROVIDER: S-EPMC12465689 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature