High-density genome-wide association study points out major candidate genes for resistance to infectious pancreatic necrosis in rainbow trout.

ABSTRACT:

Background

This study focuses on genetic resistance to infectious pancreatic necrosis (IPN), a highly contagious disease caused by an aquatic birnavirus (IPNV) which especially affects salmonids worldwide. The objectives were to estimate the heritability of IPN resistance and to fine map quantitative trait loci (QTL) using a Bayesian Sparse Linear Mixed Model to identify candidate genes possibly linked to IPN resistance in two successive generations from a French commercial strain of rainbow trout. For each generation, 2000 fish were experimentally exposed by bath to IPNV and mortalities were monitored daily during 5 weeks. All fish were genotyped using a medium-density 57 K single nucleotide polymorphism (SNP) chip and imputed to high-density genotypes (665 K SNPs).

Results

SUBMITTER: D'Ambrosio J 

PROVIDER: S-EPMC12465772 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature