Prevalence, dynamic change and spatial distribution of HIV-1 CRF119_0107 from 2019 to 2024 in Nanjing, China: a genomic and spatial epidemiological analysis.

ABSTRACT:

Background

Since its initial detection among men who have sex with men (MSM) in Nanjing, CRF119_0107 has rapidly emerged as the third most prevalent HIV-1 subtype. To elucidate its transmission dynamic, spatial characteristics, and the prevalence of transmitted drug resistance (TDR), we conducted a joint genomic and spatial epidemiological analysis.

Methods

HIV-infected individuals diagnosed from 2109 to 2024 who were identified as CRF119_0107 and didn't undergo antiretroviral therapy (ART) were included in the study. The HIV-1 pol gene sequence was obtained by viral RNA extraction and nested PCR. A molecular transmission network was constructed using HIV-TRACE, and spatial analysis was performed in ArcGIS. Multivariate logistic regression was employed to analyze factors ass

SUBMITTER: Xu Y 

PROVIDER: S-EPMC12465800 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature