Mediation of fasting blood glucose between relative muscle strength and hypertension: insights from two cohorts.

ABSTRACT:

Background

Hypertension and type 2 diabetes are major global health burdens and often coexist due to shared metabolic risk factors. Relative muscle strength (RMS), a composite measure of muscle function, shows an inverse association with hypertension. The mechanisms underlying this link remain unclear. Elevated fasting blood glucose (FBG) reflects impaired glucose metabolism and insulin resistance and is associated with both reduced muscle strength and higher blood pressure. This suggests that FBG may partly mediate the RMS-hypertension relationship. Yet, large-scale population studies have rarely tested this mediating pathway, leaving an important knowledge gap.

Methods

We analyzed data from two nationally representative cohorts: NHANES (2011-2014;adults aged ≥ 18 Years, me

SUBMITTER: Wang P 

PROVIDER: S-EPMC12465812 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature