Investigating the relationship between glymphatic dysfunction and motor symptoms in Parkinson's disease.

ABSTRACT: The glymphatic system is instrumental in cerebral waste drainage, and its impairment is mechanistically linked to the pathogenesis of neurodegenerative diseases like Parkinson's disease (PD). Nevertheless, the relationship between dysfunction in the clearance processes and the intensity of motor symptoms in PD remains inadequately characterized. This study applied the non-invasive Diffusion Tensor Image Analysis along the Perivascular Space technique to quantify the clearance network activity in PD patients compared with healthy controls (HCs), probing its prospects as an imaging biomarker for motor impairment. From January 2024 to June 2025, a total of 43 PD patients, diagnosed according to the clinical diagnostic criteria, along with 31 well-matched HCs, were enrolled. All participants u

SUBMITTER: Ma X 

PROVIDER: S-EPMC12465828 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature