Diosmetin ameliorates inflammation and apoptosis in the pathomechanism of PCOS through the NRF2/AKT/PPARγ signalling pathway.

ABSTRACT:

Ethnopharmacological relevance

Diosmetin (DIO) is a flavonoid extracted from the traditional Chinese medicine Schizonepeta tenuifolia Briq. The anti-inflammatory and neuroprotective properties of DIO have shown promise. However, the underlying mechanisms need further elucidation.

Study aim

This research aimed to explore how DIO reduces oxidative stress and inflammation in the ovaries and slows the pathological development of polycystic ovary syndrome by influencing the AKT/PPARγ signalling pathway.

Materials and methods

DIO targets were screened via network pharmacology tools. The protective effect of DIO on polycystic ovary syndrome was assessed via haematoxylin‒eosin (H&E) staining. Immunohistochemical staining, enzyme-linked immunosorbent assay (ELISA), and immunof

SUBMITTER: Chen M 

PROVIDER: S-EPMC12465927 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature