PINK1 functions in mitophagy and mitochondrial homeostasis during mice oocyte maturation.

ABSTRACT:

Background

As a serine/threonine kinase, PINK1 (PTEN-induced putative kinase 1) is widely expressed in mammalian tissues and cells, especially in the female reproductive system. However, its role in meiotic oocytes remains obscure. Here, we report that murine oocytes overexpressing Pink1 are unable to completely progress through meiosis.

Results

In the present study, we found that PINK1 protein levels in aged oocytes showed a substantial increase. Importantly, we revealed that murine oocytes overexpressing Pink1 are unable to completely progress through meiosis. This leads to inadequate mitochondrial redistribution, an elevated reactive oxygen species (ROS) level, severely disrupted spindle/chromosome organization, and abnormal mitophagy. Furthermore, we noted that elevated

SUBMITTER: Wang S 

PROVIDER: S-EPMC12465932 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature