Aberrant neuronal firing: a paracrine route to glioblastoma expansion.

ABSTRACT:

Background

Glioblastoma multiforme (GBM) is a highly aggressive astrocytic glioma with a devastating survival rate of less than 7%. Despite treatment with surgical resection and chemoradiotherapy, a majority of GBM cases recur. The intricate tumor microenvironment and the elusive nature of its recurrence are still controversial. Herein, we explore the role of neuronal hyperstimulation in glioblastoma cell regrowth post-chemotherapy, focusing on cancer-neuron interactions.

Methods

A direct electrical stimulation system, validated by COMSOL Multiphysics simulation, was used to induce stimulation of neuronal networks through the formation of an extremely low frequency (ELF) electric field, and changes by excitability were tracked. The custom-designed co-culture system, enabling

SUBMITTER: Lee JY 

PROVIDER: S-EPMC12465965 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature