Determinants of de novo mutations in extended pedigrees of 43 dog breeds.

ABSTRACT:

Background

Understanding the determinants of de novo mutation is critical for elucidating evolutionary processes and genetic disease susceptibility. But the interplay between life history, genomic architecture, and recombination remains poorly understood in non-model species. Domestic dogs, lacking the recombination regulator PRDM9 and subject to intense artificial selection, offer a unique system for dissecting factors that jointly influence mutation accumulation. Here, we leverage large-scale trio sequencing to unravel the determinants of de novo mutations across diverse dog breeds.

Results

By analyzing 390 trios from 43 breeds, we estimate a germline mutation rate of 4.89 × 10^-9 per base pair per generation. Parental age, especially paternal age, strongly influ

SUBMITTER: Zhang SJ 

PROVIDER: S-EPMC12465969 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature