Clinical efficacy and safety of somatic cell therapy for chronic low back pain: evidence from the pooled randomized controlled trials.

ABSTRACT:

Background

Chronic low back pain (CLBP) is a highly prevalent and burdensome musculoskeletal disorder globally, significantly impacting individuals' health and quality of life. This study aimed to evaluate the efficacy and safety of the somatic cell therapies in treating CLBP.

Methods

All relevant randomized controlled trials (RCTs) in the Cochrane, Embase, PubMed, and Web of Science databases were systematically searched for the meta-analysis. The outcomes consisted of Visual Analogue Scale (VAS) scores, Oswestry Disability Index (ODI) scores, and the incidence of serious adverse events (SAE). Dichotomous outcomes were described as odds ratios (OR) with 95% confidence intervals (CIs), while continuous data were presented as mean difference (MD) with 95% CIs. Statistical ana

SUBMITTER: Li Z 

PROVIDER: S-EPMC12465977 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature