Identification and experimental validation of biomarkers associated with the endocannabinoid system in major depressive disorder.

ABSTRACT:

Background

The endocannabinoid system (ES) plays a pivotal role in modulating central nervous system activity in response to emotional stimuli. This study aimed to identify and validate biomarkers associated with ES-related genes (ES-RGs) in major depressive disorder (MDD), providing insights into potential therapeutic targets.

Methods

Datasets GSE52790 and GSE38206 were analyzed in this study. Overlapping differential expression analysis and weighted gene co-expression network analysis (WGCNA) were integrated to identify intersecting genes. Candidate genes were selected through protein-protein interaction (PPI) analysis. Biomarker identification involved the integration of machine learning techniques, gene expression data, and receiver operating characteristic (ROC) analysi

SUBMITTER: Wang L 

PROVIDER: S-EPMC12466068 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature