Enhanced antibacterial effect of blue light in combination with an Amazonian tree sap (Croton lechleri).

ABSTRACT: In the United States, 8.2 million patients suffer from non-healing wounds which are often infected with antibiotic-resistant bacteria. Blue light (BL) and Sangre de Drago (Croton lechleri, SD) have potent mechanisms of antibacterial action through free radical formation and anti-biofilm effect, respectively. The aim of this pilot study was to evaluate the enhanced antibacterial effect of a novel combination treatment consisting of blue light and Sangre de Drago. Preliminary dosimetry measurements for effective SD concentration (5%) and 415-nm blue LED light fluence (125.3 J/cm² with a standard variation of 5 mW) were performed. E. coli K-12 (volume 0.1-mL, concentration 2 × 10⁵CFU/mL) was applied to each of 32 tryptic soy agar (TSA) plates. Inoculated TSA plates were

SUBMITTER: Manstein D 

PROVIDER: S-EPMC12466101 | biostudies-literature | 2025 Sep-Oct

REPOSITORIES: biostudies-literature