Bile acid pathways in Caprinae gut microbiota: adaptive shifts in microbial metabolism and community structure.

ABSTRACT:

Introduction

The gut microbiota plays a central role in host metabolism and immunity, in part through bile acid (BA) biotransformation. In Caprinae animals such as goats and sheep, this process is critical for nutrient absorption, immune regulation, and intestinal homeostasis, yet the microbial taxa and functional pathways involved remain poorly characterized.

Methods

By leveraging 7,530 high-quality non-redundant metagenome-assembled genomes (MAGs) from Caprinae gut microbiomes, this study systematically characterized microbial diversity, taxonomic composition, and bile acid (BA)-related metabolic pathways through genome annotation, phylogenetic inference, and statistical analyses.

Result

The results revealed a diverse gut microbiota across 28 phyla, with Bacillot

SUBMITTER: Shang KM 

PROVIDER: S-EPMC12466152 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature