Impact of systemic SARS-CoV-2 vaccination on mucosal IgA responses to subsequent breakthrough infection.

ABSTRACT:

Background

Mucosal IgA responses are central to protection against SARS-CoV-2 infection and viral transmission. While systemic immunity following SARS-CoV-2 infection and vaccination is thoroughly investigated, we have limited understanding of factors affecting the generation and boosting of mucosal IgA.

Methods

In this cohort study, we investigated factors influencing mucosal SARS-CoV-2 IgA responses among 879 healthcare workers enrolled in the longitudinal COMMUNITY study. Blood samples and clinical data were collected from all participants every four months since April 2020. SARS-CoV-2 immune histories are well characterized through national vaccine and infection registries along with regular monitoring of seroconversion of spike and/or nucleocapsid antigen. Regression mo

SUBMITTER: Marking U 

PROVIDER: S-EPMC12466159 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature