An Aberrant Resurgence of Endogenous Retroviruses Prompts Myocarditis and Heart Failure.

ABSTRACT:

Background

Endogenous retroviruses (ERVs) occupy >8% of the human genome. Aberrant resurgence of ERVs has been implicated recently in several critical pathologies. However, the possible incidence and role of ERV resurgence in heart failure (HF), a leading cause of global morbidity and mortality, remain unexplored.

Methods

We established a total RNA sequencing analyzing pipeline to assess the ERV occurrence in human and murine HF models. We generated 2 myocardium-specific mouse lines by crossing Myh6-MerCreMer (Myosin heavy chain 6 promoter driving MerCreMer recombinase) with TRIM28^f/f and SETDB1^f/f mice to identify the molecular regulators of ERV resurgence and the downstream pathways in the heart. We evaluated ERV expression by tot

SUBMITTER: Xiong J 

PROVIDER: S-EPMC12466171 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature