Septin4 Regulates Cardiac Fibrosis After Pressure Overload.

ABSTRACT:

Background

In response to cardiac injury the mammalian heart undergoes ventricular remodeling to maintain cardiac function. These changes are initially considered compensatory, but eventually lead to increased cardiomyocyte apoptosis, reduced cardiac function and fibrosis which are important contributors to the development of heart failure. The small GTPase Sept4 (Septin4) has previously been implicated in the regulation of regeneration and apoptosis in several organs. However, the role of Sept4 in regulating the response of the heart to stress is unknown.

Methods

Ten-week-old wild-type (WT) and Sept4 knockout mice were subjected to transverse aortic constriction to induce cardiac injury. Genotype-dependent differences were investigated at baseline and at 1- and 4-week posti

SUBMITTER: Yucel D 

PROVIDER: S-EPMC12466173 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature